FEAST: A FLOW CYTOMETRY-BASED TOOLKIT FOR INTERROGATING MICROGLIAL ENGULFMENT OF SYNAPTIC AND MYELIN PROTEINS

FEAST: A flow cytometry-based toolkit for interrogating microglial engulfment of synaptic and myelin proteins

Abstract Although engulfment is a hallmark of microglia function, fully validated platforms that facilitate high-throughput quantification of this process are lacking.Here, we present FEAST (Flow cytometric Engulfment Assay for Specific Target proteins), which enables interrogation of in vivo engulfment of synaptic material by brain resident macrop

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STATE AUDIT AS MEANS TO COUNTERACT WITH THE BUREAUCRACY

The article covers issues related to the nature and development of the state audit in Russia.Special attention is given to the place and the role of the state audit in the system of Handlebar wire public management.The author notes the special role of the Audit chamber of the Russian Federation Tobacco and the institution of the state audit as a wh

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Evaluation of the Four-Dimensional Ensemble-Variational Hybrid Data Assimilation with Self-Consistent Regional Background Error Covariance for Improved Hurricane Intensity Forecasts

The feasibility of a hurricane initialization framework based on the Gridpoint Statistical Interpolation (GSI)-based four-dimensional ensemble-variational (GSI-4DEnVar) hybrid data assimilation system for the Hurricane Weather Research and Forecasting model (HWRF) model is evaluated in this study.The system considers the temporal evolution of error

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